Microwave seminar | 09 August 2021

Human body has a high transmittance coefficient for near-infrared light. Therefore, dyes with notable absorbance peaks in the near-infrared range have a variety of applications in diagnostics. Whereas one of the main liver functions is blood purification, the rate of removal of dye from the blood is direct index of liver functionality. Indocyanine green is used to measure liver function with plasma disappearance rate parameter. Dynamic measurement of dye concentration in human blood in vivo allows to calculate plasma disappearance rate. Thereby, our setup is intended to be applied for liver function assessment. Indocyanine green changes its absorbance spectra when bounded with plasma proteins. To simulate conditions of a medical test we use 10% albumen solution as a medium for indocyanine green. Bounded with albumen indocyanine green has an absorption peak on 805 nm, similar to this bounded in human blood plasma, while in water solution indocyanine green has an absorption peak on 790 nm. The absorption analysis method of solution concentration determination is considered. We present an automated pho-tometry setup for measurement of the dye concentration in solution.

Main paper/arXiv, related to the seminar, and other references

Main paper/arXiv, related to the seminar, and other references

1. Kolokolnikov I. et al. Photometry Setup for Dynamic Dye Concentration Measurement //International Youth Conference on Electronics, Telecommunications and Information Technologies. – Springer, Cham, 2021. – С. 277-282.
2. Savchenko E. et al. Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry //Diagnostics. – 2020. – Т. 10. – №. 8. – С. 599.