Theoretical seminar | 19 January 2022
Real-time temperature monitoring within biological objects is a key fundamental issue for understanding the heating process and performing remote-controlled release of bioactive compounds upon laser irradiation. The lack of accurate thermal control significantly limits the translation of optical laser techniques into nanomedicine. Here, we design and develop two different thermally sensitive platforms. The first one represents hybrid carriers based on multilayered capsules combined with nanodiamonds (NV centers) as nanothermometers and gold nanoparticles as nanoheaters to estimate an effective laser-induced temperature rise required for capsule rupture and further release of cargo molecules outside and inside cancerous (B16-F10) cells. The second platform is based on thermally responsive polymer PNIPAM modified with gold and silicon nanoparticles
Gerasimova, Elena & Yaroshenko, Vitaly & Talianov, Pavel & Peltek, Oleksii & Baranov, Mikhail & Kapitanova, Polina & Zuev, Dmitry & Timin, Alexander & Zyuzin, Mikhail. (2021). Real-Time Temperature Monitoring of Photoinduced Cargo Release inside Living Cells Using Hybrid Capsules Decorated with Gold Nanoparticles and Fluorescent Nanodiamonds. ACS Applied Materials & Interfaces. 13. 10.1021/acsami.1c05252.